This appears to be a well known issue when using Trend Micro with "Unauthorized Change Prevention Service". Watching the task manager when doing many of the tasks and I could see this service jump to the top.
Unfortunately, many of the TM options are dependent on this service, but at the end of the day I'm a firm believer that machines need to be speedy, so I disabled the service. Note: I also disabled the Behavior Monitoring as this is dependent on the service.
If you're reading this while "thinking" of moving to Trend Micro I would advice you to take a test drive first. I've found several issues which support is working through, but it's been a bumpy road.
- Extreme slowdown when scheduled scans run (as opposed to what we're used to seeing with Webroot).
- Unauthorized Change Prevention Service slowdown.
- Issue with builds prior to 6.7.1319 being unable to restore to domain OU's.
- Issue with many of our installs prior to 6.7.1319 being unable to update to latest build automatically - support still looking into issue.